The science behind NMN

NMN improves aerobic capacity and running performance in amateur runners

Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021 Jul 8;18(1):54. doi: 10.1186/s12970-021-00442-4. PMID: 34238308; PMCID: PMC8265078.

Danese E, Tarperi C, Salvagno GL, Guzzo A, Sanchis-Gomar F, Festa L, Bertinato L, Montagnana M, Schena F, Lippi G. Sympatho-adrenergic activation by endurance exercise: Effect on metanephrines spillover and its role in predicting athlete's performance. Oncotarget. 2018 Feb 26;9(21):15650-15657. doi: 10.18632/oncotarget.24584. PMID: 29643999; PMCID: PMC5884654.

NMN protects against cognitive impairment

Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016 Jul 15;1643:1-9. doi: 10.1016/j.brainres.2016.04.060. Epub 2016 Apr 26. PMID: 27130898.

Campbell JM. Supplementation with NAD⁺ and Its Precursors to Prevent Cognitive Decline across Disease Contexts. Nutrients. 2022 Aug 7;14(15):3231. doi: 10.3390/nu14153231. PMID: 35956406; PMCID: PMC9370773.

NMN slows down aging in lung cells

Fang T, Yang J, Liu L, Xiao H, Wei X. Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells. MedComm (2020). 2021 May 27;2(2):279-287. doi: 10.1002/mco2.62. PMID: 34766147; PMCID: PMC8491199.

Taking NMN is safe and increases NAD+ levels

Soma M, Lalam SK. The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions. Mol Biol Rep. 2022 Oct;49(10):9737-9748. doi: 10.1007/s11033-022-07459-1. Epub 2022 Apr 20. PMID: 35441939.

Fletcher RS, Ratajczak J, Doig CL, Oakey LA, Callingham R, Da Silva Xavier G, Garten A, Elhassan YS, Redpath P, Migaud ME, Philp A, Brenner C, Canto C, Lavery GG. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Mol Metab. 2017 May 29;6(8):819-832. doi: 10.1016/j.molmet.2017.05.011. PMID: 28752046; PMCID: PMC5518663.

Igarashi M, Nakagawa-Nagahama Y, Miura M, Kashiwabara K, Yaku K, Sawada M, Sekine R, Fukamizu Y, Sato T, Sakurai T, Sato J, Ino K, Kubota N, Nakagawa T, Kadowaki T, Yamauchi T. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022 May 1;8(1):5. doi: 10.1038/s41514-022-00084-z. PMID: 35927255; PMCID: PMC9158788.

Okabe K, Yaku K, Uchida Y, Fukamizu Y, Sato T, Sakurai T, Tobe K, Nakagawa T. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Front Nutr. 2022 Apr 11;9:868640. doi: 10.3389/fnut.2022.868640. PMID: 35479740; PMCID: PMC9036060.